GLP-1/GLP-1R signalling in infectious diseases: basic biology, immunometabolic mechanisms, and therapeutic translation
This narrative review evaluates GLP-1/GLP-1R signalling in infection, assessing the effects of GLP-1 receptor agonists (GLP-1RAs) on metabolism, immunity, and inflammation. The study distinguishes pathogen models from endotoxin models and analyzes receptor-dependent versus systemic effects. The review indicates that GLP-1RAs consistently attenuate inflammation and tissue injury but have variable effects on pathogen clearance. Current human evidence is mainly from observational studies, lacking data on treatment initiation during acute infection.
What to check after reading
Current evidence does not establish GLP-1RAs as direct anti-infective therapies; they are regarded as candidate host-directed adjuncts.
Source
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