Context-dependent functions of insulin, IGF, and GLP signaling in inflammatory bowel disease
This review summarizes current knowledge regarding the biological functions and molecular mechanisms of insulin, IGFs, IGFBPs, and GLPs in IBD. IBD is a chronic relapsing inflammatory disorder of the gastrointestinal tract. Insulin signaling plays context-dependent roles in IBD by regulating glucose metabolism, epithelial repair, and inflammatory responses. The IGF axis is also profoundly altered during active IBD. GLP signaling further integrates metabolism with intestinal immunity; GLP-1 receptor agonists exhibit anti-inflammatory, metabolic, and microbiota-modulating effects. Emerging preclinical and observational clinical studies suggest that GLP-based therapies may improve disease outcomes, although prospective randomized trials are still required.
What to check after reading
This review summarizes the roles of insulin, IGF, and GLP in IBD, noting that GLP-1 receptor agonists have anti-inflammatory and metabolic effects, but prospective randomized trials are still required.
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