Comparative effects of pharmacological treatment for weight gain in patients treated with antipsychotics
Researchers conducted a systematic review and network meta-analysis of randomized controlled trials to compare drugs for reducing weight gain caused by antipsychotic medications. The analysis included 27 studies evaluating 17 drugs. Results showed that nizatidine and metformin were superior to placebo in short-term interventions, while liraglutide, exenatide, metformin, and samidorphan showed significant benefits in long-term interventions. Liraglutide ranked highest in SUCRA analysis.
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The study compared various drugs, but results may be limited by study duration and drug types.
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